Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis
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چکیده
منابع مشابه
Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis
Hexokinases II (HK2) is a hub in the regulation of cancer cell glycolysis. Here we reported deguelin, a natural compound which has been studied in various tumor types, has a profound anti-tumor effect on human non-small cell lung cancer (NSCLC) via directly down-regulating of glycolysis. In NSCLC cell lines and primary NSCLC tissue, we found HK2 is overexpressed. Deguelin treatment markedly inh...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.15937